International Review of Ophthalmology ›› 2022, Vol. 46 ›› Issue (5): 471-477.doi: 10.3760/ cma.j.issn.1673-5803.2022.05.016

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Correlation between type 2 diabetes mellitus and primary open angle glaucoma

Liu Jinlong, Hu Haijian, Zhang Xu   

  1. Affiliated Eye Hospital of Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science，Jiangxi Clinical Research Center of Ophthalmic Disease，Jiangxi Branch of National Clinical Research Center for Ocular Diseases, Nanchang 330006, China
  • Received:2022-05-08 Online:2022-10-22 Published:2022-11-04
  • Contact: Zhang Xu, Email: xuzhang19@163.com E-mail:xuzhang19@163.com
  • Supported by:
    National Natural Science Foundation of China（81860170）; Natural Science Foundation of Jiangxi Province（20181ACG70010）

Abstract: Glaucoma and diabetic eye disease are both serious vision-threatening diseases worldwide. Patients with type 2 diabetes mellitus (T2DM) may be accompanied by optic nerve degeneration and retinal ganglion cells（RGC) apoptosis, which are similar to the optic nerve damage of primary open-angle glaucoma (POAG). Risk factors such as high intraocular pressure, vasculopathy and retinal thinning in patients with T2DM may aggravate the progression of POAG, while pharmacological treatments for diabetes such as metforminmay have a protective effect on POAG. Further exploration of the relationship between T2DM and POAG may help reduce the risk of visual impairment in patients with T2DM and discover new treatment target for POAG.(Int Rev Ophthalmol, 2022, 46: 471-477)

Key words: primary open angle glaucoma, type 2 diabetes mellitus, optic nerve, blood flow regulation